Structures of K0.05Na0.95NbO3 (50–300 K) and K0.30Na0.70NbO3 (100–200 K)

Rietveld refinement using neutron powder diffraction data is reported for the potential lead-free piezoelectric material KxNa1 - xNbO3 (x = 0.05, x = 0.3) at low temperatures. The structures were determined to be of rhombohedral symmetry, space group R3c, with the tilt system a-a-a- for both compositions. It was found that some of the structural parameters differ significantly in the two structures, and particularly the NbO6 octahedral strains as a function of temperature. The 300 K profile for K0.05Na0.95NbO3 shows the coexistence of rhombohedral and monoclinic phases, which indicates that the phase boundary is close to room temperature; the phase boundary for K0.30Na0.70NbO3 is found to be at approximately 180 K

The effect of magnetic mirror force on the field-aligned acceleration of plasmas

A magnetic mirror effect on the field-aligned acceleration of plasma flow is discussed for anisotropic plasma conditions by incorporating double adiabatic equations of state. In a non-uniform distribution of the field magnitude along the field lines, it is found that the field-aligned acceleration is toward higher field intensity region for the fluid of low thermal energy, while the acceleration is toward lower field intensity region for the fluid of high thermal energy. We infer that perpendicular pressure would cause such an energy-dependent behavior of the field-aligned acceleration through the magnetic mirror force

Applied Randomized Algorithms for Efficient Genomic Analysis

The scope and scale of biological data continues to grow at an exponential clip, driven by advances in genetic sequencing, annotation and widespread adoption of surveillance efforts. For instance, the Sequence Read Archive (SRA) now contains more than 25 petabases of public data, while RefSeq, a collection of reference genomes, recently surpassed 100,000 complete genomes. In the process, it has outgrown the practical reach of many traditional algorithmic approaches in both time and space. Motivated by this extreme scale, this thesis details efficient methods for clustering and summarizing large collections of sequence data. While our primary area of interest is biological sequences, these approaches largely apply to sequence collections of any type, including natural language, software source code, and graph structured data. We applied recent advances in randomized algorithms to practical problems. We used MinHash and HyperLogLog, both examples of Locality- Sensitive Hashing, as well as coresets, which are approximate representations for finite sum problems, to build methods capable of scaling to billions of items. Ultimately, these are all derived from variations on sampling. We combined these advances with hardware-based optimizations and incorporated into free and open-source software libraries (sketch, frp, lib- simdsampling) and practical software tools built on these libraries (Dashing, Minicore, Dashing 2), empowering users to interact practically with colossal datasets on commodity hardware

Relativistic Electron Losses in the Outer Radiation Belts

Relativistic electrons in the magnetosphere are both energized and lost via their interaction with plasma waves such as whister chorus, plasmaspheric hiss and EMIC waves. These waves are usually localized in different regions of the magnetosphere as well as being located either inside or outside the plasmapause. We study relativistic electron losses in the outer radiation belts by characterizing decay times scales at low and high altitudes and their relationship to microbursts. We use data collected by SAMPEX, a low Earth orbiting spacecraft in a highly inclined polar orbit and the HEO spacecraft in a high altitude Molniya orbit. The sensors onboard these spacecraft measure electrons of energies > 0.6 MeV, > 1 MeV, > 3 MeV, 2-6 MeV, 3-16 MeV. High time resolution data enable identifying and characterizing electron microbursts observed at low altitudes

Electron Micro Bursts as a Mechanism of Electron Loss Via Wave-Particle Interactions

Electron microbursts are rapid fluctuations of electron fluxes occurring on time scales of milliseconds. They are thought be due to scattering into the loss cone by plasma waves of various types from chorus to the recently observed large amplitude whistlers. They may be a major process of loss of realtivistic electrons from the Earth's outer radiation belts. One of the key issues that new mission s such as RBSP will address is to understand the loss of relativistic electrons. The SAMPEX mission launched in 1992 and still collecting data has the HILT sensor onboard with the capability of measuring> 1 MeV electrons with a high time resolution of 20 milliseconds suited admirably for the study of microbursts. We will use the data collected by the HILT for over a decade to characterize the relationship between electron microbursts and macroscopic electron decay lifetimes. With the launch of RBSP it is expected that SAMPEX will continue to collect data and overlap with RBSP. The latter will provide valuable information regarding plasma waves which coupled with low altitude measurements of microbursts may help elucidate details of the physics of electron loss from the radiation belt

Corticosterone Acts in the Nucleus Accumbens to Enhance Dopamine Signaling and Potentiate Reinstatement of Cocaine Seeking

Stressful life events are important contributors to relapse in recovering cocaine addicts, but the mechanisms by which they influence motivational systems are poorly understood. Studies suggest that stress may “set the stage” for relapse by increasing the sensitivity of brain reward circuits to drug-associated stimuli. We examined the effects of stress and corticosterone on behavioral and neurochemical responses of rats to a cocaine prime after cocaine self-administration and extinction. Exposure of rats to acute electric footshock stress did not by itself reinstate drug-seeking behavior but potentiated reinstatement in response to a subthreshold dose of cocaine. This effect of stress was not observed in adrenalectomized animals, and was reproduced in nonstressed animals by administration of corticosterone at a dose that reproduced stress-induced plasma levels. Pretreatment with the glucocorticoid receptor antagonist RU38486 did not block the corticosterone effect. Corticosterone potentiated cocaine-induced increases in extracellular dopamine in the nucleus accumbens (NAc), and pharmacological blockade of NAc dopamine receptors blocked corticosterone-induced potentiation of reinstatement. Intra-accumbens administration of corticosterone reproduced the behavioral effects of stress and systemic corticosterone. Corticosterone treatment acutely decreased NAc dopamine clearance measured by fast-scan cyclic voltammetry, suggesting that inhibition of uptake2-mediated dopamine clearance may underlie corticosterone effects. Consistent with this hypothesis, intra-accumbens administration of the uptake2 inhibitor normetanephrine potentiated cocaine-induced reinstatement. Expression of organic cation transporter 3, a corticosterone-sensitive uptake2 transporter, was detected on NAc neurons. These findings reveal a novel mechanism by which stress hormones can rapidly regulate dopamine signaling and contribute to the impact of stress on drug intake

Mercury Orbiter: Report of the Science Working Team

The results are presented of the Mercury Orbiter Science Working Team which held three workshops in 1988 to 1989 under the auspices of the Space Physics and Planetary Exploration Divisions of NASA Headquarters. Spacecraft engineering and mission design studies at the Jet Propulsion Lab were conducted in parallel with this effort and are detailed elsewhere. The findings of the engineering study, summarized herein, indicate that spin stabilized spacecraft carrying comprehensive particles and fields experiments and key planetology instruments in high elliptical orbits can survive and function in Mercury orbit without costly sun shields and active cooling systems

Wave-induced loss of ultra-relativistic electrons in the Van Allen radiation belts.

The dipole configuration of the Earth's magnetic field allows for the trapping of highly energetic particles, which form the radiation belts. Although significant advances have been made in understanding the acceleration mechanisms in the radiation belts, the loss processes remain poorly understood. Unique observations on 17 January 2013 provide detailed information throughout the belts on the energy spectrum and pitch angle (angle between the velocity of a particle and the magnetic field) distribution of electrons up to ultra-relativistic energies. Here we show that although relativistic electrons are enhanced, ultra-relativistic electrons become depleted and distributions of particles show very clear telltale signatures of electromagnetic ion cyclotron wave-induced loss. Comparisons between observations and modelling of the evolution of the electron flux and pitch angle show that electromagnetic ion cyclotron waves provide the dominant loss mechanism at ultra-relativistic energies and produce a profound dropout of the ultra-relativistic radiation belt fluxes